Alice wakes up in the Raccoon City hospital after the area has been overrun by zombies, and must now make it out of the city before a nuclear bomb is dropped.
As the city is locked down under quarantine, Alice joins a small band of elite soldiers, enlisted to rescue the missing daughter of the creator of the mutating T-virus. It's a heart-pounding race against time as the group faces off against hordes of blood- thirsty zombies, stealthy Lickers, mutant canines and the most sinister foe yet.